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Organometallic compounds contain direct bonds between carbon atoms and metal atoms/ions and play roles as homogeneous catalysts and stoichiometric reagents in reactions; available in various chemical compositions, quantities, purities, and reagent grades.
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Aminooxy-PEG3-C2-NH-Boc is a PEG- and Alkyl/ether-based PROTAC linker designed for the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
Suitable for PROTAC synthesis
Molecular weight: 308.37
Targeted for PROTAC linkers pathway
Recommended storage: 4°C, sealed, away from moisture and light (solid); -80°C for 6 months or -20°C for 1 month (in solvent)
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Tos-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It can also be used for the synthesis of 3'-aminooxy oligonucleotides solid supports. PROTACs consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, and they exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Peg-based PROTAC linker.
Used in the synthesis of PROTACs.
Used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
PROTACs degrade target proteins using the ubiquitin-proteasome system.
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Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Functions as a click chemistry reagent with an azide group
Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne groups
Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Facilitates selective degradation of target proteins through the intracellular ubiquitin-proteasome system
Intended for research use only
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Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent containing an Azide group, enabling it to participate in various cycloaddition reactions. PROTACs are designed to degrade target proteins via the intracellular ubiquitin-proteasome system.
Utilized in the synthesis of PROTACs
Functions as a click chemistry reagent
Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups
Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
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Azido-PEG3-SSPy is a cleavable three-unit polyethylene glycol (PEG3) linker that contains an azide functional group and a disulfide-pyridyldithiol (SSPy) moiety; it is designed for bioconjugation and ADC linker synthesis using click chemistry.
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N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
PEG-based PROTAC linker
Utilized in PROTAC synthesis
Applicable in cancer-programmed cell death research
Connects two different ligands for PROTAC formation
Targets E3 ubiquitin ligase and protein of interest
Exploits intracellular ubiquitin-proteasome system
Selectively degrades target proteins
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Br-PEG3-MS is a brominated, PEG-based PROTAC linker (methanesulfonate) designed for use in chemical synthesis of PROTACs and other bifunctional molecules. It provides a short PEG3 spacer with a reactive leaving group for conjugation chemistry, enabling efficient formation of linkages between ligands under standard organic conditions. For research use only.
PEG3 spacer with a terminal bromide and methanesulfonate leaving group.
Suitable for linker synthesis and nucleophilic substitution reactions.
High purity (95.0% by NMR) for reliable synthetic performance.
Low molecular weight facilitates handling in small-scale reactions.
Available in multiple small pack sizes to support medicinal chemistry workflows.
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N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This compound acts as a click chemistry reagent, featuring an Azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions when combined with Alkyne groups. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Functions as a click chemistry reagent
Contains an Azide group
Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups
Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More